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St. Joseph's College, Sasse is a secondary school in the Southwest Region of Cameroon, with its campus located in Sasse, Buea. It was created in 1939 by the Mill Hill Missionaries.

Affiliated with the Catholic faith as an all-male institution, it provides education at the first cycle and high school levels, offering programs in science and arts. In 2012, Sasse college was awarded the prize of the best school in West Africa.

St Joseph’s College started timidly in Bonjongo, Buea, in 1937. The Mill Hill Missionaries later moved it to Sasse in 1939 as a Minor Seminary, where most of the students graduated and moved to the Major Seminary in Oweri, Nigeria. Initially inaugurated with two dormitories only, a kitchen, a science laboratory and a handful of students, Sasse has grown in leaps and bounds.

The motto of the school is Fides Quarens Intellectum meaning 'Faith seeking Understanding'.